Drug carriers have been generally used for drug management launch, enhancing drug efficacy and/or minimizing side-effects. Nonetheless, it’s nonetheless tough to get a excessive loading effectivity when encapsulating tremendous hydrophilic medication with a slim therapeutic index, equivalent to many neurotoxins. Growing the provider proportion can enhance drug loading to a sure diploma, whereas the burst launched drug when the formulation enters the physique might trigger overdose side-effects. Furthermore, high-dose carriers themselves might enhance the metabolic burden of the physique. Therefore, new drug carriers and/or loading methods are urgently wanted to advertise the purposes of those medication. This minireview will introduce drug loading methods based mostly on particular interactions (between medication and carriers) and can focus on the challenges and views of those methods. This work is predicted to supply various inspiration for the supply of hydrophilic medication.