The sector of nanomaterials has progressed dramatically over the previous many years with vital contributions to the biomedical space. The physicochemical properties of nanomaterials, reminiscent of the dimensions and construction, may be managed via manipulation of mass and warmth switch situations throughout synthesis. Specifically, microfluidic methods with fast mixing and exact fluid management are ideally suited platforms for creating applicable synthesis situations. One notable instance of microfluidics-based synthesis is the event of lipid nanoparticle (LNP)-based mRNA vaccines with accelerated scientific translation and strong efficacy in the course of the COVID-19 pandemic. Along with LNPs, microfluidic methods have been adopted for the managed synthesis of a broad vary of nanomaterials. On this evaluation, we introduce the elemental rules of microfluidic applied sciences together with move field- and a number of field-based strategies for fabricating nanoparticles, and talk about their purposes within the biomedical discipline. We conclude this evaluation by outlining a number of main challenges and future instructions within the implementation of microfluidic synthesis of nanomaterials.