A selenium-containing metallic–natural framework with exceptional antioxidant capability and ROS-scavenging exercise was constructed by a managed de novo encapsulation strategy of a glycoconjugate mimetic, particularly a sp²-iminoglycolipid bearing a selenoureido fragment (DSeU), inside a zeolitic-imidazolate framework exoskeleton. Biocompatible and homogeneous nanosized particles of ∼70 nm (DSeU@ZIF8) had been obtained, which could possibly be effectively internalized in cells, overcoming the poor solubility in organic media and restricted bioavailability of glycolipids. The ZIF-particle served as nanocarrier for the intracellular supply of the selenocompound to cells, promoted by the acidic pH inside endosomes/lysosomes. As demonstrated by in vitro research, the designed DSeU@ZIF8 nanoparticles displayed a excessive antioxidant exercise at low doses; decrease intracellular ROS ranges had been noticed upon the uptake of DSeU@ZIF8 by human endothelial cells. Much more attention-grabbing was the discovering that these DSeU@ZIF8 particles had been capable of reverse to a sure degree the oxidative stress induced in cells by pre-treatment with an oxidizing agent. This chance of modulating the oxidative stress in residing cells might have necessary implications within the remedy of numerous pathological issues which can be usually accompanied with elevated ROS ranges.