The hunt for cleaner pathways to the manufacturing of fuels and chemical compounds from non-fossil feedstock, environment friendly transformation of uncooked supplies to value-added chemical compounds below delicate situations, and management over the exercise and selectivity of chemical processes are driving the state-of-the-art approaches to the development and exact chemical modification of sustainable nanocatalysts. As a burgeoning class of atomically exact noble metallic nanoclusters, copper nanoclusters (Cu NCs) benefitting from their unique structural structure, ingenious designability of energetic websites and excessive surface-to-volume ratio qualify as potential rationally-designed catalysts. On this Minireview, we current an in depth protection of the optimum design methods and managed synthesis of Cu NC catalysts with a concentrate on tuning of energetic websites on the atomic degree, the implications of cluster dimension, form and construction, the ligands and heteroatom doping on catalytic exercise, and response scope starting from chemical catalysis to rising photocatalysis and electrocatalysis.